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MCAT-TEST MCAT Practice Questions

Prepare for MCAT-TEST with more than an answer.

245 questions in the full set20 sample questionsUpdated Jan 21, 2026
Exam fee
$355 USD
Level
Professional Entry
Valid for
No formal expiration, but medical schools may have policies
Domains covered on the exam 4
  1. Chemical and Physical Foundations of Biological Systems25%
  2. Critical Analysis and Reasoning Skills (CARS)25%
  3. Biological and Biochemical Foundations of Living Systems25%
  4. Psychological, Social, and Biological Foundations of Behavior25%
  1. 1

    Which of the following statements accurately describe the differences between the somatic and autonomic nervous systems? (Select TWO)

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    Correct answer: B, D

    This is a key distinction. The somatic nervous system controls voluntary movements by innervating skeletal muscles. The autonomic nervous system regulates involuntary bodily functions by controlling smooth muscle (e.g., in blood vessels, gut), cardiac muscle, and glandular secretions.

    Somatic motor neurons are exclusively cholinergic, releasing acetylcholine (ACh) to cause skeletal muscle contraction. In the autonomic system, all preganglionic neurons release ACh. Postganglionic parasympathetic neurons release ACh, while most postganglionic sympathetic neurons release norepinephrine.

  2. 2

    A researcher titrates a weak acid, HA, with a strong base, NaOH. The titration curve shows that the pH at the half-equivalence point is 4.76. What is the Ka of the weak acid HA?

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    Correct answer: B

    At the half-equivalence point of a titration of a weak acid with a strong base, the concentration of the weak acid [HA] is equal to the concentration of its conjugate base [A-]. According to the Henderson-Hasselbalch equation, pH = pKa + log([A-]/[HA]). When [A-] = [HA], the ratio is 1, and log(1) = 0. Therefore, at the half-equivalence point, pH = pKa. So, the pKa of the acid is 4.76. To find the Ka, we use the relationship Ka = 10^-pKa. Ka = 10^-4.76. Since 10^-4.76 is between 10^-4 and 10^-5, and closer to 10^-5, we can estimate it as approximately 1.74 x 10^-5.

  3. 3

    In a study on social mobility, a researcher finds that children of physicians are significantly more likely to become physicians themselves than children from other socioeconomic backgrounds. This finding is a direct example of:

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    Correct answer: C

    Social reproduction refers to the perpetuation of social inequalities, such as social class, across generations. The finding that children of physicians are more likely to become physicians demonstrates that the social standing and advantages of one generation are being passed down to the next, thus reproducing the existing social structure. This happens through the transmission of cultural capital (e.g., knowledge of the medical field) and social capital (e.g., networks).

  4. 4

    The electron transport chain (ETC) in mitochondria involves a series of redox reactions. Which of the following components of the ETC is NOT a protein complex?

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    Correct answer: C

    The electron transport chain consists of four large protein complexes (Complex I, II, III, and IV) embedded in the inner mitochondrial membrane, along with two mobile electron carriers. One of these carriers is Cytochrome c (a small protein), and the other is Coenzyme Q (also called ubiquinone). Coenzyme Q is a small, lipid-soluble molecule, not a protein complex, that shuttles electrons from Complex I and Complex II to Complex III.

  5. 5

    True or False: The Doppler effect for sound requires that either the source or the observer (or both) be in motion, while the Doppler effect for light occurs even if the source and observer are stationary, as long as the intervening medium is moving.

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    Correct answer: B

    This statement is false. The Doppler effect, for both sound and light, is caused by the relative motion between the source and the observer. Light, as an electromagnetic wave, does not require a medium for propagation. Therefore, the motion of a medium is irrelevant to the Doppler effect for light. The shift in frequency (redshift or blueshift) depends only on the relative velocity of the source and observer.

  6. 6

    A biochemist is studying a novel enzyme that displays cooperative binding kinetics. The reaction velocity is measured at various substrate concentrations, yielding a sigmoidal curve on a Michaelis-Menten plot. Which of the following structural features is most likely responsible for this observed cooperativity?

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    Correct answer: C

    Cooperative binding, characterized by a sigmoidal kinetic curve, is a hallmark of allosteric enzymes that are typically composed of multiple subunits (a multimeric structure). The binding of a substrate molecule to one active site induces a conformational change in the enzyme that is transmitted to the other subunits, altering their affinity for the substrate. This communication between subunits is the basis of cooperativity. A single active site cannot exhibit cooperativity. Non-competitive inhibitors affect Vmax but do not induce the characteristic sigmoidal curve of positive cooperativity. Covalent modification is a form of regulation but is not the direct structural cause of cooperativity itself.

  7. 7

    A researcher designs a study to assess the impact of stereotype threat on the performance of female students in an advanced physics course. Which of the following study designs would best isolate the effect of stereotype threat? (Select TWO)

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    Correct answer: B, E

    This design directly manipulates the independent variable (stereotype threat activation) and measures its effect on the dependent variable (test performance) while using random assignment to control for confounding variables. This is a classic experimental design to test for stereotype threat.

    This design tests stereotype threat by manipulating the context. Describing the test as 'diagnostic' is known to invoke stereotype threat for stereotyped groups, while framing it as a neutral 'problem-solving task' mitigates this threat. Comparing performance between these two randomly assigned groups effectively isolates the effect.

  8. 8

    When separating a mixture of amino acids—valine (isoelectric point = 6.0), lysine (pI = 9.7), and aspartic acid (pI = 2.8)—using ion-exchange chromatography with a cation-exchange column at a pH of 6.0, what is the expected order of elution?

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    Correct answer: B

    At pH 6.0, aspartic acid (pI=2.8) is well above its pI and will have a net negative charge. Valine (pI=6.0) will have a net charge of zero. Lysine (pI=9.7) is well below its pI and will have a net positive charge. A cation-exchange column contains a negatively charged stationary phase. Therefore, the negatively charged aspartic acid will be repelled and elute first. The neutral valine will have minimal interaction and elute next. The positively charged lysine will bind tightly to the column and elute last, likely requiring a change in buffer pH or salt concentration to be released.

  9. 9

    A medical student is analyzing the pressure-volume loop of the left ventricle for a patient with chronic hypertension. Compared to a healthy individual, the hypertensive patient's loop would most likely exhibit:

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    Correct answer: C

    Chronic hypertension increases the afterload, which is the pressure the left ventricle must overcome to eject blood into the aorta. This requires the ventricle to generate a higher pressure during systole, leading to an increased end-systolic pressure. The increased afterload makes it harder for the ventricle to eject blood, resulting in a larger end-systolic volume and consequently a smaller stroke volume (the width of the PV loop). The loop shifts to the right and becomes taller and narrower.

  10. 10

    True or False: In operant conditioning, negative reinforcement involves the removal of an aversive stimulus to increase the likelihood of a behavior, whereas punishment involves the presentation of an aversive stimulus to decrease the likelihood of a behavior.

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    Correct answer: A

    This statement is true. Negative reinforcement strengthens a behavior by removing an unpleasant stimulus (e.g., taking an aspirin removes a headache, making you more likely to take aspirin for future headaches). Punishment (specifically, positive punishment) weakens a behavior by adding an unpleasant stimulus (e.g., getting a speeding ticket makes you less likely to speed). The key distinction is that reinforcement (both positive and negative) always increases a behavior, while punishment always decreases a behavior.

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